Deep Neural Networks (DNNs) suffer from domain shift when the test dataset follows adistribution different from the training dataset. Domain generalization aims to tackle this issue by learning a model that can generalize to unseen domains.

Out-of-context misinformation (OOC) is a low-cost form of misinformation in news reports, which refers to place authentic images into out-of-context or fabricated image-text pairings. This problem has attracted significant attention from researchers in recent years. Current methods focus on assessing image-text consistency or generating explanations. However, these approaches assume that the training and test data are drawn from the same distribution. When encountering novel news domains, models tend to perform poorly due to the lack of prior knowledge. To address this challenge, we propose \textbf{VDT} to enhance the domain adaptation capability for OOC misinformation detection by learning domain-invariant features and test-time training mechanisms. Domain-Invariant Variational Align module is employed to jointly encodes source and target domain data to learn a separable distributional space domain-invariant features. For preserving semantic integrity, we utilize domain consistency constraint module to reconstruct the source and target domain latent distribution. During testing phase, we adopt the test-time training strategy and confidence-variance filtering module to dynamically updating the VAE encoder and classifier, facilitating the model's adaptation to the target domain distribution. Extensive experiments conducted on the benchmark dataset NewsCLIPpings demonstrate that our method outperforms state-of-the-art baselines under most domain adaptation settings.

Abstract--Deep learning-based automatic sleep staging has significantly advanced in performance and plays a crucial role in the diagnosis of sleep disorders. However, those models often struggle to generalize on unseen subjects due to variability in physiological signals, resulting in degraded performance in out-of-distribution scenarios. T o address this issue, domain generalization approaches have recently been studied to ensure generalized performance on unseen domains during training. Among those techniques, contrastive learning has proven its validity in learning domain-invariant features by aligning samples of the same class across different domains. Despite its potential, many existing methods are insufficient to extract adequately domain-invariant representations, as they do not explicitly address domain characteristics embedded within the unshared information across samples. In this paper, we posit that mitigating such domain-relevant attributes--referred to as excess domain-relevant information--is key to bridging the domain gap. However, the direct strategy to mitigate the domain-relevant attributes often overfits features at the high-level information, limiting their ability to leverage the diverse temporal and spectral information encoded in the multiple feature levels. T o address these limitations, we propose a novel MEASURE (Multi-scalE minimAl SUfficient Representation lEarning) framework, which effectively reduces domain-relevant information while preserving essential temporal and spectral features for sleep stage classification. In our exhaustive experiments on publicly available sleep staging benchmark datasets, SleepEDF-20 and MASS, our proposed method consistently outperformed state-of-the-art methods.

However, selecting intermediate domains without explicit metadata remains a substantial challenge that has not been extensively explored in existing studies. T o tackle this issue, we propose a novel framework that combines reinforcement learning with feature disentanglement to conduct domain path selection in an unsupervised CDA setting. Our approach introduces an innovative unsupervised reward mechanism that leverages the distances between latent domain embeddings to facilitate the identification of optimal transfer paths. Furthermore, by disentangling features, our method facilitates the calculation of unsupervised rewards using domain-specific features and promotes domain adaptation by aligning domain-invariant features. This integrated strategy is designed to simultaneously optimize transfer paths and target task performance, enhancing the effectiveness of domain adaptation processes. Extensive empirical evaluations on datasets such as Rotated MNIST and ADNI demonstrate substantial improvements in prediction accuracy and domain selection efficiency, establishing our method's superiority over traditional CDA approaches.

Resting-state functional magnetic resonance imaging (rs-fMRI) and its derived functional connectivity networks (FCNs) have become critical for understanding neurological disorders. However, collaborative analyses and the generalizability of models still face significant challenges due to privacy regulations and the non-IID (non-independent and identically distributed) property of multiple data sources. To mitigate these difficulties, we propose Domain Adversarial Federated Learning (DAFed), a novel federated deep learning framework specifically designed for non-IID fMRI data analysis in multi-site settings. DAFed addresses these challenges through feature disentanglement, decomposing the latent feature space into domain-invariant and domain-specific components, to ensure robust global learning while preserving local data specificity. Furthermore, adversarial training facilitates effective knowledge transfer between labeled and unlabeled datasets, while a contrastive learning module enhances the global representation of domain-invariant features. We evaluated DAFed on the diagnosis of autism spectrum disorder (ASD) and further validated its generalizability in the classification of Alzheimer's disease (AD), demonstrating its superior classification accuracy compared to state-of-the-art methods. Additionally, an enhanced Score-CAM module identifies key brain regions and functional connectivity significantly associated with ASD and mild cognitive impairment (MCI), respectively, uncovering shared neurobiological patterns across sites. These findings highlight the potential of DAFed to advance multi-site collaborative research in neuroimaging while protecting data confidentiality. Introduction Resting-state functional magnetic resonance imaging (rs-fMRI) has emerged as a powerful and non-invasive technique for detecting abnormal brain activity [1]. Functional connectivity networks (FCNs), derived from rs-fMRI data, quantify temporal correlations between functional interactions in different brain regions, which are extensively utilized in studies of neurological disorders and mental illnesses [2, 3]. Recently, deep learning approaches have shown remarkable potential in analyzing fMRI data and FCNs, enabling significant breakthroughs in understanding brain function [4, 5]. Despite significant advancements in deep learning models, concerns over patient privacy and legal restrictions limit data sharing across institutions. This limitation poses challenges to the reproducibility and generalizability of data-driven approaches across diverse datasets [6, 7].

When conducting large-scale studies that collect brain MR images from multiple facilities, the impact of differences in imaging equipment and protocols at each site cannot be ignored, and this domain gap has become a significant issue in recent years. In this study, we propose a new low-dimensional representation (LDR) acquisition method called style encoder adversarial domain adaptation (SE-ADA) to realize content-based image retrieval (CBIR) of brain MR images. SE-ADA reduces domain differences while preserving pathological features by separating domain-specific information from LDR and minimizing domain differences using adversarial learning. In evaluation experiments comparing SE-ADA with recent domain harmonization methods on eight public brain MR datasets (ADNI1/2/3, OASIS1/2/3/4, PPMI), SE-ADA effectively removed domain information while preserving key aspects of the original brain structure and demonstrated the highest disease search accuracy.